Protein Kinase C (PKC)

Cat. No.

A46240

CAS No.

25090-74-8

12-Deoxyphorbol 13-isobutyrate

12-Deoxyphorbol 13-isobutyrate is a potent activator of PKCα, derived from the latex of Euphorbia resinifera. It enhances the proliferation and activation of neural stem cells (NSCs) and promotes the release of TGFα, demonstrating a significant role in neurogenesis. Additionally, this compound has been shown to improve cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models, making it a valuable reagent for research into neurodegenerative diseases.

Cat. No.

A46253

CAS No.

2566-89-4

Methyl arachidonate

Synonyms: Arachidonic acid methyl ester

Methyl arachidonate is an activator of protein kinase C, functioning as an orally active substrate that is subject to esterase-mediated hydrolysis. It promotes the indirect activation of protein kinase C through the generation of eicosanoid metabolites from the arachidonic acid metabolic pathway, demonstrating differential effects via cyclooxygenase products at low concentrations and lipoxygenase products at elevated concentrations. This compound is valuable for investigations into mechanisms related to lipodystrophy.

Cat. No.

A46259

CAS No.

156604-45-4

Farnesylthiotriazole

Synonyms: FTT

Farnesylthiotriazole (FTT) is a potent activator of protein kinase C (PKC), with a dissociation constant (Kd) of 0.8 μM. This compound plays a significant role in various signaling pathways, making it a valuable tool in cancer research. Its ability to modulate PKC activity can aid in the investigation of tumor biology and therapeutic strategies targeting PKC-related pathways.

Cat. No.

A46260

CAS No.

91125-76-7

1-Oleoyl-2-linoleoyl-sn-glycerol

1-Oleoyl-2-linoleoyl-sn-glycerol is a diacylglycerol that acts as an activator of protein kinase C (PKC). This activation initiates downstream signaling cascades that are vital in promoting tumor growth, making it a relevant compound for cancer research. Its role in the signaling pathways related to breast cancer highlights its potential use in studying tumorigenesis and therapeutic strategies.

Cat. No.

A46261

CAS No.

322647-32-5

1,2-Dipentadecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium

1,2-Dipentadecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium is a potent activator of the protein kinase C (PKC) family. This anionic phospholipid is integral to mitochondrial and microsomal membranes, significantly contributing to the composition and function of lung surfactant, particularly within lamellar body membranes in the lungs. Its unique properties make it a valuable tool for studying PKC-mediated signaling pathways and lung physiology.

Cat. No.

A52270

CAS No.

60562-16-5

1,2-Dimyristoyl-sn-glycerol

1,2-Dimyristoyl-sn-glycerol is a saturated diacylglycerol that acts as a weak second messenger for the activation of Protein Kinase C (PKC). This compound is utilized in research applications to study PKC signaling pathways, which are crucial in various cellular processes including growth, differentiation, and apoptosis. As a PKC activator, it can help elucidate the role of PKC in different biological contexts and disease models.