Protein Kinase C (PKC)

Cat. No.

A14336

CAS No.

56124-62-0

Valrubicin

Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin.

Cat. No.

A14871

CAS No.

113731-96-7

PKC (19-36)

PKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM).

Cat. No.

A14882

CAS No.

136795-05-6

[Ser25] Protein Kinase C (19-31)

Protein Kinase C (19-31), this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity.

Cat. No.

A15557

CAS No.

193620-69-8

TAS 301

TAS 301 is an inhibitor of smooth muscle cell migration and proliferation.

Cat. No.

A15617

CAS No.

2034-69-7

Daphnoretin

Synonyms: Dephnoretin; Thymelol

Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity. Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst.

Cat. No.

A15644

CAS No.

30220-46-3

Ingenol

Synonyms: (-)-Ingenol

Ingenol is a potent activator of protein kinase C (PKC), exhibiting a Ki value of 30 μM. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. Ingenol can be utilized to explore the role of PKC in various signaling pathways and to investigate its potential therapeutic applications in oncology.

Cat. No.

A15699

CAS No.

5928-25-6

Decursin

Synonyms: (+)-Decursin

Decursin is an anticancer agent, with potential anti-inflammatory activity.

Cat. No.

A16212

CAS No.

1046787-18-1

PKC-IN-1

PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1.

Cat. No.

A16213

CAS No.

785718-37-8

NSC305787

NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 uM, 9.4 uM, 55 uM for PKC phosphorylation of recombinant ezrin, of moesin, and of radixin.

Cat. No.

A16604

CAS No.

169939-93-9

Ruboxistaurin (LY333531 HCl)

Synonyms: LY-333531

LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.

Cat. No.

A17019

CAS No.

84468-24-6

HA-100 (C1)

Synonyms: HA100

HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50 = 8, 12, and 4 μM, respectively).

Cat. No.

A18627

CAS No.

1564249-38-2

BJE6-106

Synonyms: B-106

BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM).

Cat. No.

A18966

CAS No.

1160501-81-4

PKC-theta inhibitor 1

PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM.

Cat. No.

A19279

CAS No.

121569-61-7

UCN-02

Synonyms: 7-epi-Hydroxystaurosporine

UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively.

Cat. No.

A19347

CAS No.

1321924-70-2

VTX-27

VTX-27 is a selective protein kinase C θ (PKC θ) inhibitor, with Kis of 0.08 nM and 16 nM for PKC θ and PKC δ.

Cat. No.

A19419

CAS No.

1874276-76-2

Darovasertib (LXS196)

Synonyms: LXS 196

Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma.

Cat. No.

A19712

CAS No.

736048-65-0

PKC-theta inhibitor

PKC-theta inhibitor is a selective PKC-θinhibitor, with an IC50 of 12 nM.

Cat. No.

A19795

CAS No.

865608-11-3

CMPD101

CMPD101, is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM. CMPD101 also inhibits ROCK-2 and PKCα (IC50s=1.4 μM and 8.1 μM, respectively).

Cat. No.

A19943

CAS No.

28399-31-7

DCP-LA

Synonyms: FR236924

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε.

Cat. No.

A20740

CAS No.

37558-16-0

Phorbol 12,13-dibutyrate

Synonyms: Phorbol dibutyrate; PDBu

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter.

Cat. No.

A20743

CAS No.

82-08-6

Rottlerin

Synonyms: Mallotoxin; NSC 56346; NSC 94525

Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM.

Cat. No.

A21368

CAS No.

56687-67-3

DCPLA-ME

Synonyms: DCPLA methyl ester

DCPLA-ME, the methyl ester form of DCPLA, is a potent PKCε activator for use in the treatment of neurodegenerative diseases.

Cat. No.

A21581

CAS No.

1214726-89-2

AS2521780

AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM.

Cat. No.

A21611

CAS No.

56092-81-0

Ionomycin

Synonyms: SQ23377

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus.

Cat. No.

A21765

CAS No.

125314-64-9

Ro 31-8220

Synonyms: Bisindolylmaleimide IX

Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.