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Poneratoxin

Catalog No.: A68528
Peptide Toxin
Poneratoxin is a peptide toxin that acts as a modulator of voltage-gated sodium channels (NaV), specifically NaV1.6 and NaV1.7, with EC50 values of 97 nM and 2.3 µM, respectively. It lowers the voltage threshold for channel activation and inhibits their inactivation, thereby enhancing neuronal excitability. This activity is relevant in studies of pain signal transmission and neuropathic pain research, making Poneratoxin a valuable tool in neurobiology and pharmacological investigations.
Poneratoxin 137084-94-7 Peptide Toxin
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPoneratoxin is a peptide toxin that acts as a modulator of voltage-gated sodium channels (NaV), specifically NaV1.6 and NaV1.7, with EC50 values of 97 nM and 2.3 µM, respectively. It lowers the voltage threshold for channel activation and inhibits their inactivation, thereby enhancing neuronal excitability. This activity is relevant in studies of pain signal transmission and neuropathic pain research, making Poneratoxin a valuable tool in neurobiology and pharmacological investigations.
Product Information
Catalog NumA68528
FormulaC129H215N33O31S
Molecular Weight2756.35
CAS Number137084-94-7
SequencePhe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2
Sequence shorteningFLPLLILGSLLMTPPVIQAIHDAQR-NH2
SMILESC(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@H](CC3=CC=CC=C3)N)=O)CC(C)C)=O)CCC2)CC(C)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CC(C)C)=O)=O)CO)=O)CC(C)C)=O)CC(C)C)=O)CCSC)=O)[C@@H](C)O)=O)CCC1)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CCC(N)=O)=O)C)=O)CC(O)=O)=O)=O)[C@H](CC)C)=O)C)=O)CCC(N)=O)=O)[C@H](CC)C)=O)[C@@H](C)C)=O)CCC4
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