PRMT5-IN-55

Catalog No.: A26659
Histone Methyltransferase Inhibitor
PRMT5-IN-55 is a selective inhibitor of the histone methyltransferase PRMT5, demonstrating a pIC50 value of 9.6 at a concentration of 10 nM. This compound plays a crucial role in modulating epigenetic processes by inhibiting arginine methylation, which can influence gene expression and cellular differentiation. PRMT5-IN-55 is valuable for research applications focused on cancer biology, epigenetics, and the therapeutic exploration of PRMT5 in various diseases.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPRMT5-IN-55 is a selective inhibitor of the histone methyltransferase PRMT5, demonstrating a pIC50 value of 9.6 at a concentration of 10 nM. This compound plays a crucial role in modulating epigenetic processes by inhibiting arginine methylation, which can influence gene expression and cellular differentiation. PRMT5-IN-55 is valuable for research applications focused on cancer biology, epigenetics, and the therapeutic exploration of PRMT5 in various diseases.
Product Information
Catalog NumA26659
FormulaC22H24N6O2
Molecular Weight404.46
CAS Number2086772-19-0
SMILESNC1=NC2=CC(CC[C@H]3C[C@H]([C@@H]([C@@H]3O)O)N4C=CC5=C4N=CN=C5N)=CC=C2C=C1
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