PRMT5 ligand 3

Catalog No.: A26645
PRMT5 Ligand
PRMT5 ligand 3 (Compound S19) is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), a key enzyme involved in epigenetic regulation. This compound plays a crucial role in the development of PROTACs (Proteolysis Targeting Chimeras) aimed at targeting PRMT5 for degradation, thereby facilitating research into cancer and other diseases characterized by dysregulated methylation. PRMT5 ligand 3 is essential for studies focused on the therapeutic potential of targeted protein degradation strategies.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPRMT5 ligand 3 (Compound S19) is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), a key enzyme involved in epigenetic regulation. This compound plays a crucial role in the development of PROTACs (Proteolysis Targeting Chimeras) aimed at targeting PRMT5 for degradation, thereby facilitating research into cancer and other diseases characterized by dysregulated methylation. PRMT5 ligand 3 is essential for studies focused on the therapeutic potential of targeted protein degradation strategies.
Product Information
Catalog NumA26645
FormulaC17H19ClN4O2
Molecular Weight346.81
CAS Number1616397-61-5
SMILESClC1=CC(C(NC[C@H](O)CN2CC(C=CC=C3)=C3CC2)=O)=NC=N1
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