(R)-AMG-193 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), functioning as a methionine adenosine transferase (MTA)-cooperative inhibitor. This compound demonstrates significant antitumor activity, particularly in MTAP-deficient tumor cells, with an IC50 value of 0.107 μM. It effectively inhibits PRMT5, allowing for the preferential targeting of tumor cells while sparing normal cells with intact MTAP. (R)-AMG-193 is a valuable tool for research into cancer biology and therapeutic strategies involving PRMT5 inhibition.
(R)-AMG-193 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), functioning as a methionine adenosine transferase (MTA)-cooperative inhibitor. This compound demonstrates significant antitumor activity, particularly in MTAP-deficient tumor cells, with an IC50 value of 0.107 μM. It effectively inhibits PRMT5, allowing for the preferential targeting of tumor cells while sparing normal cells with intact MTAP. (R)-AMG-193 is a valuable tool for research into cancer biology and therapeutic strategies involving PRMT5 inhibition.
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