PRMT5-MTA-IN-3 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), demonstrating potent biological activity with an IC50 of 5 nM in inhibiting cell proliferation within the MTAP-deficient colorectal cancer cell line HCT-116. This compound is particularly relevant for research focused on cancers associated with MTAP deficiencies, including colorectal cancer, non-small cell lung cancer, and pancreatic cancer, making it a valuable tool for cancer biology studies aimed at targeting PRMT5.
PRMT5-MTA-IN-3 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), demonstrating potent biological activity with an IC50 of 5 nM in inhibiting cell proliferation within the MTAP-deficient colorectal cancer cell line HCT-116. This compound is particularly relevant for research focused on cancers associated with MTAP deficiencies, including colorectal cancer, non-small cell lung cancer, and pancreatic cancer, making it a valuable tool for cancer biology studies aimed at targeting PRMT5.
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