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PROTAC Linker

PROTAC linkers connect the target-protein ligand and the E3 ligase ligand of a proteolysis-targeting chimera (PROTAC). Linker length, flexibility and attachment chemistry influence whether the two ligands can bring the target and the ligase together in a ternary complex. The range includes alkyl-chain and polyethylene glycol (PEG) linkers, such as NH2-C2-NH-Boc and Cl-C6-PEG4-O-CH2COOH, with reactive or protected ends for stepwise synthesis. Some linkers already carry a ligase-binding group, for example VH032-PEG5-C6-Cl for von Hippel-Lindau (VHL) and Pomalidomide-PEG4-C-COOH for cereblon. Ready-made ligand-linker conjugates and complete degraders are listed in the neighboring PROTAC categories.

Cat. No.

A41481

CAS No.

2720500-49-0

STING agonist-20-Ala-amide-PEG2-C2-NH2

STING agonist-20-Ala-amide-PEG2-C2-NH2 serves as an active scaffold targeting the stimulator of interferon genes (STING) pathway. This compound exhibits significant immune activation and can be utilized in the synthesis of immune-stimulating antibody conjugates (ISAC) for enhanced immunotherapeutic applications. Its primary use lies in cancer research, facilitating investigations into the modulation of immune responses against tumor cells.

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PROTAC Linker

STING agonist-20-Ala-amide-PEG2-C2-NH2