20-Hydroxyvitamin D3 serves as a VDR agonist, modulating immune responses without inducing calcemia. By binding to the vitamin D receptor (VDR), it activates VDR and aryl hydrocarbon receptor (AhR) signaling pathways, enhances CYP24A1 expression, and promotes VDR nuclear translocation. This compound inhibits NF-κB activity through IκBα upregulation, demonstrating anti-proliferative effects in cancer cells by reducing cell proliferation, colony formation, migration, and tumor growth while inducing differentiation. 20-Hydroxyvitamin D3 is a valuable tool for investigating inflammatory and autoimmune diseases, as well as various cancers, including melanoma and hepatocarcinoma.
20-Hydroxyvitamin D3 serves as a VDR agonist, modulating immune responses without inducing calcemia. By binding to the vitamin D receptor (VDR), it activates VDR and aryl hydrocarbon receptor (AhR) signaling pathways, enhances CYP24A1 expression, and promotes VDR nuclear translocation. This compound inhibits NF-κB activity through IκBα upregulation, demonstrating anti-proliferative effects in cancer cells by reducing cell proliferation, colony formation, migration, and tumor growth while inducing differentiation. 20-Hydroxyvitamin D3 is a valuable tool for investigating inflammatory and autoimmune diseases, as well as various cancers, including melanoma and hepatocarcinoma.
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