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EGFR/HER2

EGFR and HER2 inhibitors act on two closely related receptor tyrosine kinases of the ErbB family. The epidermal growth factor receptor (EGFR, ErbB1) and human epidermal growth factor receptor 2 (HER2, ErbB2) form dimers with each other and with ErbB3 and ErbB4. Receptor activation engages the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) pathways that control cell growth. Activating EGFR mutations in non-small-cell lung cancer have made the receptor a central model in kinase inhibitor research. Gefitinib and erlotinib are reversible EGFR inhibitors, and lapatinib inhibits both EGFR and HER2. Osimertinib binds covalently to EGFR carrying the T790M resistance mutation, and neratinib irreversibly inhibits HER2 and EGFR.

2 Items

  • pp60 (v-SRC) Autophosphorylation Site, Phosphorylated
    Cat. No.
    A28572
    CAS No.
    176042-83-4

    pp60 (v-SRC) Autophosphorylation Site, Phosphorylated

    pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is a phosphorylated peptide that serves as a substrate for the epidermal growth factor receptor (EGFR). This product is utilized for the evaluation of EGFR kinase inhibitors through the quantification of phosphorylated substrates, aiding in the exploration of signaling pathways and potential therapeutic applications in cancer research. Its precise autophosphorylation site makes it an essential tool for discerning kinase activity in various biological assays.

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    Out of stock

    All 3 sizes
  • EGFR Protein Tyrosine Kinase Substrate
    Cat. No.
    A28946
    CAS No.
    945830-38-6

    EGFR Protein Tyrosine Kinase Substrate

    EGFR Protein Tyrosine Kinase Substrate serves as a substrate for the Epidermal Growth Factor Receptor (EGFR), facilitating the study of EGFR-mediated signaling pathways. This substrate is essential for investigating the catalytic activity of EGFR and its role in cellular processes such as proliferation and differentiation. It is particularly useful in research applications focusing on cancer biology, targeted therapies, and the development of EGFR inhibitors.

    In stock View Details
    5 mg
    $40.00
    10 mg
    $65.00
    All 4 sizes

2 Items

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