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Ephrin Receptor

Ephrin receptor inhibitors act on erythropoietin-producing hepatocellular (Eph) receptor kinases. Eph receptors form the largest family of receptor tyrosine kinases, and the first member was cloned in 1987 from a hepatocellular carcinoma cell line. A-type receptors (EphA) mainly bind ephrin-A ligands anchored by a glycolipid. B-type receptors (EphB) bind ephrin-B ligands that span the membrane of the opposing cell. Contact between cells starts bidirectional signaling into both the receptor cell and the ligand cell. This signaling guides axons, sets tissue boundaries and shapes blood vessels, and it is studied in tumor cell migration. ALW-II-41-27 inhibits several Eph kinases, and EphB4-IN-1 is directed at the EphB4 receptor. UniPR1331 blocks the Eph-ephrin interaction itself, while 150D4 is listed as an EphA4 agonist.

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  • EPHB4 modulator-1
    Cat. No.
    A84704
    CAS No.
    633281-74-0

    EPHB4 modulator-1

    EPHB4 modulator-1 is a selective modulator of the Ephrin Type-B Receptor 4 (EPHB4), which plays a crucial role in cell signaling and developmental processes. This compound demonstrates significant ability to influence EPHB4-mediated signaling pathways, making it a valuable tool for researching angiogenesis and tumor progression. It is particularly relevant for studies examining the role of EPHB4 in vascular biology and its potential implications in cancer therapy.

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