- Cat. No.
- A22564
LM11A-31 HCl
Synonyms: LM11A-31 hydrochloride; LM11A-31
LM11A-31 is a small-molecule p75NTR modulator and proNGF antagonist.
In stock
View Details
-
-
- Cat. No.
- A28700
IGF-1R modulator 1
IGF-1R modulator 1 is a selective modulator of the insulin-like growth factor 1 receptor (IGF-1R), exhibiting EC50 values of 0.25 μM for IGF-1R, alongside notable activity against FGFR1, TrkA, and TrkB. This compound is valuable in the study of pathological conditions associated with dysregulated signaling of neurotrophins and trophic factors, including Alzheimer's disease. Its efficacy in modulating IGF-1R offers potential insights into therapeutic approaches for neurodegenerative disorders.
In stock View Details -
- Cat. No.
- A34999
PTX-BD10-2
Synonyms: BD10-2
PTX-BD10-2 is an orally active modulator of TrkB/C that demonstrates protective effects against basal forebrain cholinergic neuron (BFCN) degeneration. This compound has been shown to restore cholinergic neurite integrity and alleviate cholinergic neurite atrophy. PTX-BD10-2 serves as a valuable tool in research focused on Alzheimer's disease and related neurodegenerative disorders.
Out of stock
All 3 sizes -
- Cat. No.
- B10833
(Rac)-LM11A-31 dihydrochloride
(Rac)-LM11A-31 dihydrochloride is an isomer of the LM11A-31 compound, functioning as a non-peptide modulator targeting the p75 neurotrophin receptor (p75NTR). This compound exhibits potent antagonistic activity against proNGF (nerve growth factor), making it valuable for research in neurodegenerative diseases and neurobiology. Its oral bioavailability and efficacy position it as a useful tool in studying the role of nerve growth factors in various cellular processes.
In stock View Details