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IGF-1R

IGF-1R inhibitors act on the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase. Its primary structure, reported in 1986, revealed close homology with the insulin receptor, especially in the tyrosine kinase domain. Insulin-like growth factors I and II activate the receptor, which signals through the phosphoinositide 3-kinase (PI3K) and Akt pathway. The two receptors are so similar that many inhibitors in this set also act on the insulin receptor. NVP-AEW541, characterized in 2004, discriminates IGF-1R from the insulin receptor in cellular assays. Linsitinib, BMS-754807 and PQ 401 are further IGF-1R inhibitors, and the Insulin Receptor category lists related compounds.

2 Items

  • SU 4313
    Cat. No.
    A22672
    CAS No.
    186611-55-2

    SU 4313

    SU-4313 is a small-molecule modulator of protein tyrosine kinases (PTKs). It inhibits multiple receptor tyrosine kinases with reported IC₅₀ values of 14.5 μM (PDGFR), 18.8 μM (FLK-1/VEGFR2), 11 μM (EGFR), 16.9 μM (HER2 kinase), and 8.0 μM (IGF-1R). Through its multi-kinase inhibitory profile, SU-4313 modulates tyrosine kinase–mediated signal transduction pathways involved in the regulation of cell proliferation and growth. It is therefore commonly used as a research tool for investigating aberrant receptor tyrosine kinase signaling and proliferation-associated pathways.  

    In stock View Details
    1 mg
    $30.00
    2 mg
    $45.00
    All 8 sizes
  • IGF-1R modulator 1
    Cat. No.
    A28700
    CAS No.
    2375424-89-6

    IGF-1R modulator 1

    IGF-1R modulator 1 is a selective modulator of the insulin-like growth factor 1 receptor (IGF-1R), exhibiting EC50 values of 0.25 μM for IGF-1R, alongside notable activity against FGFR1, TrkA, and TrkB. This compound is valuable in the study of pathological conditions associated with dysregulated signaling of neurotrophins and trophic factors, including Alzheimer's disease. Its efficacy in modulating IGF-1R offers potential insights into therapeutic approaches for neurodegenerative disorders.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

2 Items

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