RO 16-6491 Free Base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), demonstrating high affinity for its binding sites in human frontal cortex mitochondria and platelet membranes. This compound exhibits fast dissociation of bound radioactivity at 20 degrees Celsius, highlighting its dynamic binding properties. Additionally, as a substrate for MAO-B, RO 16-6491 may generate a stable intermediate that contributes to its potent inhibitory effects. This dye functions as an effective radioligand probe for examining the regional distribution of MAO-B in various physiological and pathological contexts.
RO 16-6491 Free Base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), demonstrating high affinity for its binding sites in human frontal cortex mitochondria and platelet membranes. This compound exhibits fast dissociation of bound radioactivity at 20 degrees Celsius, highlighting its dynamic binding properties. Additionally, as a substrate for MAO-B, RO 16-6491 may generate a stable intermediate that contributes to its potent inhibitory effects. This dye functions as an effective radioligand probe for examining the regional distribution of MAO-B in various physiological and pathological contexts.
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