SB 334867

Catalog No.: A12786

OX1 receptor antagonist

SB 334867

SB 334867 Chemical Structure

CAS NO. 249889-64-3

SB 334867 is a selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$75.00
25 mg
$150.00
50 mg
$250.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 PMID: 27992882

Biological Activity

SB 334867 is a selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.32 mL 156.58 mL 313.17 mL
0.5 mM 6.26 mL 31.32 mL 62.63 mL
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL

*The above data is based on the productmolecular weight 319.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12786
Actions Antagonist
CAS No. 249889-64-3
Formula C17H13N5O2
M. Wt 319.32
Purity >98%
Synonyms SB334867,SB-334867
SMILES CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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