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Publications citing Adooq Products
SB 334867 Citations (1)
- Tony Ngo,et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 27992882
Chemical Information
| Catalog Num | A12786 |
|---|---|
| Actions | Antagonist |
| M. Wt | 319.32 |
| Formula | C17H13N5O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 249889-64-3 |
| Synonyms | SB334867,SB-334867 |
| SMILES code | CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4 |
| Chemical Name | N-(2-Methyl-6-benzoxazolyl)-N'-1,5-n?aphthyridin-4-yl urea |
Description |
SB 334867 is a selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo. | |||||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.32 mL | 156.58 mL | 313.17mL |
| 0.5 mM | 6.26 mL | 31.32 mL | 62.63 mL |
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
*The above data is based on the productmolecular weight 319.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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