SCH 39304 is an orally active antifungal agent that demonstrates efficacy against systemic candidiasis, aspergillosis, and cryptococcosis, with median effective doses (ED50) of 0.18, 3.7, and 5.9 mg/kg in murine models. Pharmacokinetic evaluations reveal a prolonged half-life and significant systemic exposure in both mice and rats. This compound is applicable in anti-infective research, particularly for studying fungal infections and therapeutic interventions.
SCH 39304 is an orally active antifungal agent that demonstrates efficacy against systemic candidiasis, aspergillosis, and cryptococcosis, with median effective doses (ED50) of 0.18, 3.7, and 5.9 mg/kg in murine models. Pharmacokinetic evaluations reveal a prolonged half-life and significant systemic exposure in both mice and rats. This compound is applicable in anti-infective research, particularly for studying fungal infections and therapeutic interventions.
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