SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer, primarily targeting NF-κB signaling. It effectively induces TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs) at concentrations of 0.01 to 1 μM and exhibits an EC50 of 0.55 μM in cells expressing human TLR2. In vivo studies demonstrate that SMU127 (0.1 mg/animal) significantly reduces tumor volume in a 4T1 murine mammary carcinoma model, making it a valuable tool for research on immune response and cancer therapy.
SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer, primarily targeting NF-κB signaling. It effectively induces TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs) at concentrations of 0.01 to 1 μM and exhibits an EC50 of 0.55 μM in cells expressing human TLR2. In vivo studies demonstrate that SMU127 (0.1 mg/animal) significantly reduces tumor volume in a 4T1 murine mammary carcinoma model, making it a valuable tool for research on immune response and cancer therapy.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
