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Notch

Notch signaling inhibitors block a contact-dependent pathway that controls cell fate decisions. The four mammalian Notch receptors bind Delta-like and Jagged ligands presented by adjacent cells. Ligand binding triggers a first cut by an a disintegrin and metalloproteinase (ADAM) protease and a second cut by the γ-secretase complex. The second cleavage releases the Notch intracellular domain (NICD), which moves to the nucleus and switches on target genes. Notch activity shapes stem cell maintenance, T-cell development, angiogenesis and tumor growth in experimental models. γ-Secretase inhibitors such as semagacestat, MK-0752 and crenigacestat prevent NICD release. IMR-1 acts downstream and stops the coactivator Mastermind-like 1 from joining the nuclear Notch transcription complex.

1 Item

  • Jagged-1 (188-204)
    Cat. No.
    A79145
    CAS No.
    219127-21-6

    Jagged-1 (188-204)

    Jagged-1 (188-204) is a Notch agonist derived from the Jagged-1 protein, known for its role in activating the Notch signaling pathway. This peptide fragment exhibits significant biological activity by enhancing the maturation of monocyte-derived human dendritic cells. It is particularly relevant for research in multiple myeloma, where Jagged-1 is highly expressed in both cultured and primary tumor cells, making it a valuable tool for studies focused on immune response and cancer immunotherapy.

    In stock View Details
    1 mg
    $105.00
    5 mg
    $250.00
    All 6 sizes

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