SU-11752 is a potent inhibitor of DNA-dependent protein kinase (DNA-PK), exhibiting an IC50 value of 0.13 μM. This compound also inhibits the PI3K p110γ kinase with an IC50 of 1.1 μM. By competitively binding to the ATP-site of DNA-PK, SU-11752 effectively disrupts intracellular DNA double-strand break repair mechanisms, thereby enhancing the sensitivity of cells to radiotherapy. This makes it a valuable tool in cancer research and therapy applications.
SU-11752 is a potent inhibitor of DNA-dependent protein kinase (DNA-PK), exhibiting an IC50 value of 0.13 μM. This compound also inhibits the PI3K p110γ kinase with an IC50 of 1.1 μM. By competitively binding to the ATP-site of DNA-PK, SU-11752 effectively disrupts intracellular DNA double-strand break repair mechanisms, thereby enhancing the sensitivity of cells to radiotherapy. This makes it a valuable tool in cancer research and therapy applications.
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