Tenuazonic acid is a mycotoxin belonging to the tetramic acids family, functioning primarily as an inhibitor of bacterial protein biosynthesis by promoting the suppression of new protein release on ribosomes. It exhibits acute toxicity, with oral LD50 values ranging between 81-186 mg/kg in rodents. Tenuazonic acid also acts as a photosystem II inhibitor by preventing electron transport beyond the primary quinone receptor (QA) through its interaction with the D1 protein. Furthermore, this compound has demonstrated antiviral activity against various viruses, including measles and respiratory viruses, and exhibits potential inhibitory effects on skin cancer.
Tenuazonic acid is a mycotoxin belonging to the tetramic acids family, functioning primarily as an inhibitor of bacterial protein biosynthesis by promoting the suppression of new protein release on ribosomes. It exhibits acute toxicity, with oral LD50 values ranging between 81-186 mg/kg in rodents. Tenuazonic acid also acts as a photosystem II inhibitor by preventing electron transport beyond the primary quinone receptor (QA) through its interaction with the D1 protein. Furthermore, this compound has demonstrated antiviral activity against various viruses, including measles and respiratory viruses, and exhibits potential inhibitory effects on skin cancer.
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