Thifluzamide is a potent antifungal agent that targets the ubiquinone-binding site of mitochondrial complex II, effectively inhibiting fungal respiration. This compound demonstrates significant activity against Basidiomycota pathogens, including genera such as Rhizoctonia, Ustilago, and Puccinia, making it valuable in studies related to wheat sharp eyespot. Additionally, Thifluzamide plays a dual role in lipid metabolism regulation by decreasing fatty acid synthase activity and enhancing carnitine palmitoyltransferase-I activity, leading to reduced cholesterol and triglyceride levels. However, caution is advised due to its potential hepatotoxic effects observed in zebrafish models and the risk of developmental toxicity.
Thifluzamide is a potent antifungal agent that targets the ubiquinone-binding site of mitochondrial complex II, effectively inhibiting fungal respiration. This compound demonstrates significant activity against Basidiomycota pathogens, including genera such as Rhizoctonia, Ustilago, and Puccinia, making it valuable in studies related to wheat sharp eyespot. Additionally, Thifluzamide plays a dual role in lipid metabolism regulation by decreasing fatty acid synthase activity and enhancing carnitine palmitoyltransferase-I activity, leading to reduced cholesterol and triglyceride levels. However, caution is advised due to its potential hepatotoxic effects observed in zebrafish models and the risk of developmental toxicity.
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