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Calcium Channels

Calcium channel blockers act on voltage-gated channels that let calcium ions enter excitable cells. Voltage-gated calcium (CaV) channels couple membrane depolarization to muscle contraction, neurotransmitter release and gene expression. Channel types are classed as L-, N-, P/Q-, R- and T-type according to their electrophysiological and pharmacological properties. The pore-forming α1 subunit of the L-type channel was first sequenced in 1987 as the skeletal muscle receptor for calcium channel blockers. Dihydropyridines in this category include isradipine, nimodipine and amlodipine besylate, which bind L-type channels. The benzothiazepine diltiazem HCl acts on the same channel type at a distinct binding site. BAPTA/AM, the cell-permeant ester of a calcium chelator, is listed for buffering intracellular calcium rather than for blocking channels.

2 Items

  • Aladorian
    Cat. No.
    A66021
    CAS No.
    865433-00-7

    Aladorian

    Synonyms: ARM036; S44121

    Aladorian (ARM036; S44121) is a non-peptidic stabilizer of the ryanodine receptor 2 (RyR2). It effectively stabilizes RyR2 channels, addressing abnormal Ca²⁺ handling in cardiomyocytes and improving Ca²⁺ homeostasis independently of dystrophin restoration. This compound has been shown to mitigate early cardiomyopathy and enhance left ventricular function in canine models of muscular dystrophy. Aladorian is valuable for research into heart failure, cardiomyopathies associated with Duchenne muscular dystrophy, and other forms of muscular dystrophy.

    In stock View Details
    1 mg
    $310.00
    5 mg
    $740.00
    All 6 sizes
  • Aladorian sodium
    Cat. No.
    A66257
    CAS No.
    1233219-11-8

    Aladorian sodium

    Synonyms: ARM036 sodium; S44121 sodium

    Aladorian sodium is a non-peptidic stabilizer of the ryanodine receptor 2 (RyR2). It effectively stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes, thereby improving calcium homeostasis independent of dystrophin restoration. This compound has been shown to attenuate early cardiomyopathy and enhance left ventricular function in canine models of muscular dystrophy. Aladorian sodium is applicable in research related to heart failure, Duchenne muscular dystrophy-associated cardiomyopathy, and general muscular dystrophy.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

2 Items

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