UNC10201652 is a potent inhibitor of bacterial β-glucuronidase, specifically targeting Loop 1 (L1) in gut microbiota, with an IC50 value of 0.117 μM for E. coli β-glucuronidase. This compound effectively blocks the processing of SN-38 glucuronide, predominantly in individuals with a high abundance of L1 GUS enzymes in their fecal microbiota. Its application is of particular interest in studying gut microbiome interactions and drug metabolism.
UNC10201652 is a potent inhibitor of bacterial β-glucuronidase, specifically targeting Loop 1 (L1) in gut microbiota, with an IC50 value of 0.117 μM for E. coli β-glucuronidase. This compound effectively blocks the processing of SN-38 glucuronide, predominantly in individuals with a high abundance of L1 GUS enzymes in their fecal microbiota. Its application is of particular interest in studying gut microbiome interactions and drug metabolism.
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