XL-126

Catalog No.: A40534
BET Inhibitor
XL-126 is a selective inhibitor of the bromodomain and extraterminal (BET) protein family, specifically targeting BD1 with a Kd of 8.9 nM. This compound demonstrates significant anti-inflammatory properties while preserving platelet function, making it a valuable tool for research into inflammatory disorders and hematological conditions. XL-126 is particularly useful in studies aimed at understanding the role of BET proteins in disease pathways and therapeutics.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionXL-126 is a selective inhibitor of the bromodomain and extraterminal (BET) protein family, specifically targeting BD1 with a Kd of 8.9 nM. This compound demonstrates significant anti-inflammatory properties while preserving platelet function, making it a valuable tool for research into inflammatory disorders and hematological conditions. XL-126 is particularly useful in studies aimed at understanding the role of BET proteins in disease pathways and therapeutics.
Product Information
Catalog NumA40534
FormulaC33H37N7O3S
Molecular Weight611.76
CAS Number3033576-12-1
SMILESO=C1C(NC2CCNCC2)=CC(C3=CC(NS(=O)(CC)=O)=C(C4=C3)C=CN4C(C)(C5=NC=CC=C5)C6=CC=CC=N6)=CN1C
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