XOR/URAT1-IN-1 is a dual inhibitor targeting xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), exhibiting IC50 values of 6 nM and 12.9 μM, respectively. This compound effectively reduces uric acid levels in models of acute hyperuricemia induced by potassium oxonate or hypoxanthine. It serves as a valuable tool for studying disorders related to hyperuricemia and offers potential therapeutic insights for conditions such as gout.
XOR/URAT1-IN-1 is a dual inhibitor targeting xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), exhibiting IC50 values of 6 nM and 12.9 μM, respectively. This compound effectively reduces uric acid levels in models of acute hyperuricemia induced by potassium oxonate or hypoxanthine. It serves as a valuable tool for studying disorders related to hyperuricemia and offers potential therapeutic insights for conditions such as gout.
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