ZYJ-34c is a potent histone deacetylase inhibitor (HDACi) that effectively targets HDAC6 and HDAC8, exhibiting IC50 values of 0.056 μM and 0.146 μM, respectively. At low concentrations, ZYJ-34c induces G1 phase cell cycle arrest and demonstrates significant antiproliferative activity. In preclinical studies, it shows substantial antitumor effects in MDA-MB-231 and HCT116 xenograft models and reveals antimetastatic potential in a mouse hepatoma-22 (H22) pulmonary metastasis model, highlighting its applicability in cancer research.
ZYJ-34c is a potent histone deacetylase inhibitor (HDACi) that effectively targets HDAC6 and HDAC8, exhibiting IC50 values of 0.056 μM and 0.146 μM, respectively. At low concentrations, ZYJ-34c induces G1 phase cell cycle arrest and demonstrates significant antiproliferative activity. In preclinical studies, it shows substantial antitumor effects in MDA-MB-231 and HCT116 xenograft models and reveals antimetastatic potential in a mouse hepatoma-22 (H22) pulmonary metastasis model, highlighting its applicability in cancer research.
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