AMG-073 HCl (Cinacalcet HCl)

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CaSR activator

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Catalog No. A10219

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AMG-073 HCl 10mg A10219-10

Regular Price: $40.00

Special Price: $32.00

AMG-073 HCl 50mg A10219-50

Regular Price: $100.00

Special Price: $80.00

AMG-073 HCl 100mg A10219-100

Regular Price: $180.00

Special Price: $144.00

AMG-073 HCl 10mM * 1mL in DMSO A10219-10mM-D

Regular Price: $80.00

Special Price: $64.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.

AMG-073 HCl (Cinacalcet HCl)

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Chemical Information

Catalog Num A10219
Actions Activator
M. Wt 393.9
Formula C22H23ClF3N
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 364782-34-3
Synonyms Mimpara, Sensipar
SMILES code C[[email protected]](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl
Chemical Name No

Biological Activity

Description
AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.
Targets
CaSR
2.8 μM

Solubility

Solubility (25°C) * In vitro DMSO 79 mg/mL (200.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol 33 mg/mL (83.78 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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