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Fig. 1 · Structure
Cat. No.
A12002
CAS No.
7770-78-7
Formula
C21H24O6
Mol. Weight
372.42

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Arctigenin

Cat. No. A12002 CAS 7770-78-7
Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. It inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM)

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 > 50 μM Cytotoxicity against human A549 cells after 4 days under normal conditions by MTT assay [PMID: 25571795]
A549 IC50 0.8 μg/mL Antiproliferative activity against human A549 cells assessed as inhibition of cell viability by MTT assay [PMID: 32223924]
A549 IC50 6.57 μM Cytotoxicity against human A549 cells after 4 days under glucose-starved conditions by MTT assay [PMID: 25571795]
HeLa EC50 > 100 μM Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by WST-8 assay [PMID: 28754364]
HeLa IC50 572.7 μM Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay [PMID: 30237124]
HepG2 IC50 2.8 μg/mL Antiproliferative activity against human HepG2 cells assessed as inhibition of cell viability by MTT assay [PMID: 32223924]
HL-60 EC50 12 μM Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by WST-8 assay [PMID: 28754364]
MDA-MB-231 IC50 1.1 μg/mL Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability by MTT assay [PMID: 32223924]
MRC5 IC50 2.1 μM Antiviral activity against HCMV in MRC5 cells by plaque reduction assay [PMID: 17239594]
PANC-1 IC50 2.2 μM Growth inhibition of human PANC1 cells in nutrient-deprived medium incubated for 24 hrs by MTT assay [PMID: 30878830]
RAW264.7 IC50 0.26 mM Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs [PMID: 18986199]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 7770-78-7
Formula C21H24O6
Molecular Weight 372.42
Synonyms (-)-Arctigenin
SMILES
COC1=C(C=C(C=C1)C[C@H]2COC(=O)[C@@H]2CC3=CC(=C(C=C3)O)OC)OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 63 mg/mL (169.16 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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