Cellular Effect
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| MCF7 | IC50 | 53 μM | Concentration required to reduce to 50% the number of MCF-7 cells with respect to untreated control after exposure to compound for 24 h | [PMID: 12477361] |
Fig. 1 · Structure
Documents & Downloads
Bleomycin
Cat. No.
A14378
CAS
11056-06-7
Glycopeptide Antibiotic
Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. It acts by induction of DNA strand breaks.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 11056-06-7 |
| Applications | Glycopeptide Antibiotic |
| Formula | C55H84N17O21S3 |
| Molecular Weight | 1415.55 |
| Synonyms | Bleo; Bleocin; BLM |
| SMILES | CC1=C(N=C(N=C1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@@H]([C@H](C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Publications
1 publication citing this product
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Ou QX, .et al. , Bioelectrochemistry, 2017, Jun;115:47-55 PMID: 28063751