Cyt387 (Momelotinib)

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JAK inhibitor

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Catalog No. A10263

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Cyt387 10mg A10263-10

Regular Price: $90.00

Special Price: $72.00

Cyt387 25mg A10263-25

Regular Price: $160.00

Special Price: $128.00

Cyt387 50mg A10263-50

Regular Price: $280.00

Special Price: $224.00

Cyt387 200mg A10263-200

Regular Price: $800.00

Special Price: $640.00

Cyt387 10mM * 1mL in DMSO A10263-10mM-D

Regular Price: $96.00

Special Price: $76.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.

Cyt387 (Momelotinib)

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Chemical Information

Catalog Num A10263
Actions Inhibitor
M. Wt 414.5
Formula C23H22N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1056634-68-4
Synonyms CYT 11387, Cyt-387
SMILES code C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N
Chemical Name N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide

Biological Activity

Description
CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.
Targets
JAK1 JAK2 JAK3
11 nM18 nM155 nM

Solubility

Solubility (25°C) * In vitro DMSO 83 mg/mL (200.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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