Cyt387 (Momelotinib)

CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.
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Product Name Price Stock Qty
Cyt387 10mg
$90.00
In stock
Cyt387 25mg
$160.00
In stock
Cyt387 50mg
$280.00
In stock
Cyt387 200mg
$650.00
In stock
Cyt387 10mM * 1mL in DMSO
$60.00
In stock
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Adooq Products cited in reputable paper
Adooq's Cyt387 (Momelotinib) has been cited by 1 publications
  • Alex Bainbridge, .et al. , Nucleic Acids Research, 2020, April
  • Biological Activity
    Discription CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A10263
    Formula C23H22N6O2
    Molecular Weight 414.5
    CAS Number 1056634-68-4
    SMILES C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 67 mg/mL (161.65 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+40%PEG 300+ 3% Tween80 + ddH2O 1 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.13 mL 120.63 mL 241.25 mL
    0.5 mM 4.83 mL 24.13 mL 48.25 mL
    1 mM 2.41 mL 12.06 mL 24.13 mL
    5 mM 0.48 mL 2.41 mL 4.83 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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