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Biological Activity
LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.
Targets
| Target | Value |
|---|---|
| JAK2(V617F) | ki: 0.245nM |
| JAK2 | ki: 0.288nM |
| JAK2 | IC50: 2.52nM |
| FLT3 | IC50: 4nM |
| JAK1 | IC50: 19.8nM |
| FLT4 | IC50: 25nM |
| FGFR2 | IC50: 32nM |
| TYK2 | IC50: 44nM |
| JAK3 | IC50: 48.0nM |
| TrkB | IC50: 95nM |
| FGFR3 | IC50: 106nM |
| KDR | IC50: 109nM |
| ALK | IC50: 138nM |
| MUSK | IC50: 147nM |
| AuroraA | IC50: 168nM |
| MAP3K9 | IC50: 299nM |
| In vitro | DMSO | 92 mg/mL (195.76 mM) | |
| Water | Insoluble | ||
| Ethanol | 9 mg/mL (19.15 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.28 mL | 106.41 mL | 212.81 mL |
| 0.5 mM | 4.26 mL | 21.28 mL | 42.56 mL |
| 1 mM | 2.13 mL | 10.64 mL | 21.28 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
*The above data is based on the productmolecular weight 469.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10546 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1229236-86-5 |
| Formula | C23H25ClFN7O |
| M. Wt | 469.9 |
| Purity | >98% |
| SMILES | CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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