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LY2784544 (Gandotinib)

JAK inhibitor

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Catalog No. A10546

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LY2784544 5mg A10546-5
LY2784544 10mg A10546-10
LY2784544 25mg A10546-25
LY2784544 100mg A10546-100
LY2784544 10mM * 1mL in DMSO A10546-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.

LY2784544 (Gandotinib)

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Chemical Information

Catalog Num A10546
Actions Inhibitor
M. Wt 469.9
Formula C23H25ClFN7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1229236-86-5
Synonyms N/A

Biological Activity

LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.
Target Value
JAK2(V617F)ki: 0.245nM
JAK2ki: 0.288nM
JAK2IC50: 2.52nM
FLT3IC50: 4nM
JAK1IC50: 19.8nM
FLT4IC50: 25nM
FGFR2IC50: 32nM
TYK2IC50: 44nM
JAK3IC50: 48.0nM
TrkBIC50: 95nM
FGFR3IC50: 106nM
KDRIC50: 109nM
ALKIC50: 138nM
MUSKIC50: 147nM
AuroraAIC50: 168nM
MAP3K9IC50: 299nM


Solubility (25°C)* In vitro DMSO 94 mg/mL (200.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL (19.15 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.28 mL 106.41 mL 212.81mL
0.5 mM 4.26 mL 21.28 mL 42.56 mL
1 mM 2.13 mL 10.64 mL 21.28 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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