LY2784544 (Gandotinib)

Catalog No.: A10546

JAK inhibitor

LY2784544 (Gandotinib)

LY2784544 (Gandotinib) Chemical Structure

CAS NO. 1229236-86-5

LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
25 mg
$320.00
100 mg
$900.00
10mM * 1mL in DMSO
$144.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.
Targets
Target Value
JAK2(V617F)ki: 0.245nM
JAK2ki: 0.288nM
JAK2IC50: 2.52nM
FLT3IC50: 4nM
JAK1IC50: 19.8nM
FLT4IC50: 25nM
FGFR2IC50: 32nM
TYK2IC50: 44nM
JAK3IC50: 48.0nM
TrkBIC50: 95nM
FGFR3IC50: 106nM
KDRIC50: 109nM
ALKIC50: 138nM
MUSKIC50: 147nM
AuroraAIC50: 168nM
MAP3K9IC50: 299nM
In vitro DMSO 94 mg/mL (200.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL (19.15 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.28 mL 106.41 mL 212.81 mL
0.5 mM 4.26 mL 21.28 mL 42.56 mL
1 mM 2.13 mL 10.64 mL 21.28 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10546
Actions Inhibitor
M. Wt 469.9
Formula C23H25ClFN7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1229236-86-5
Synonyms N/A
SMILES CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F

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