TAK-715

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p38 MAPK inhibitor

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Catalog No. A11582

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TAK-715 10mg A11582-10

Regular Price: $110.00

Special Price: $93.50

TAK-715 25mg A11582-25

Regular Price: $220.00

Special Price: $187.00

TAK-715 50mg A11582-50

Regular Price: $320.00

Special Price: $272.00

TAK-715 100mg A11582-100

Regular Price: $550.00

Special Price: $467.50

TAK-715 10mM * 1mL in DMSO A11582-10mM-D

Regular Price: $80.00

Special Price: $68.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.

TAK-715

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Chemical Information

Catalog Num A11582
Actions Inhibitor
M. Wt 399.51
Formula C24H21N3OS
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 303162-79-0
Synonyms TAK715, TAK 715
SMILES code CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C
Chemical Name N-(4-(2-Ethyl-4-(3-methylphenyl)-thiazol-5-yl)pyridin-2-yl)benzamide

Biological Activity

Description
TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.
Targets
Target Value
p38αIC50: 7.1nM
p38βIC50: 0.20μM
p38γIC50: >10μM
p38δIC50: >10μM
JNK1IC50: >10μM
ERK1IC50: >10μM
IKKβIC50: >10μM
MEKK1IC50: >10μM
TAK1IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 80 mg/mL (200.24 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (40.04 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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