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5-HT receptor agonists and antagonists act on receptors for serotonin, also called 5-hydroxytryptamine (5-HT). Serotonin receptors are classified into seven families, 5-HT1 to 5-HT7, and most of them are G protein-coupled receptors. The 5-HT3 receptor is the exception, a serotonin-gated ion channel whose structure was reported in 1991. These receptors regulate mood, sleep, appetite, vascular tone and gut motility, so they are studied across neuroscience and physiology. Ligands in this category include WAY-100635, a 5-HT1A antagonist, and eletriptan hydrobromide, a 5-HT1B/1D agonist. Prucalopride, an agonist at the 5-HT4 receptor, is also listed.
Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
Synonyms: Ba-30803
Benzoctamine hydrochloride is a selective blocker of central postsynaptic serotonin receptors. This psychoactive agent exhibits anti-anxiety effects by decreasing serotonin (5-HT) turnover in the brain, making it relevant for research in neuropharmacology and anxiety disorders. Its mechanism of action offers insights into serotonergic signaling pathways and potential therapeutic targets for anxiety-related conditions.
