Black Friday & Year End Sale starting Nov 21st 2022 through Jan 2nd 2023, enjoy 20% off sitewide


Catalog No.: A11055

c-Met inhibitor


AMG-458 Chemical Structure

CAS NO. 913376-83-7

AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $150.00

Special Price $120.00

10 mg

Regular Price: $210.00

Special Price $168.00

50 mg

Regular Price: $620.00

Special Price $496.00

100 mg

Regular Price: $1,000.00

Special Price $800.00

10mM * 1mL in DMSO

Regular Price: $221.00

Special Price $176.80

Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2.
Target Value
c-Met(H1094R)ki: 0.5nM
c-Met(V1092I)ki: 1.1nM
c-Met(Human)ki: 1.2nM
c-Met(Mouse)ki: 2.0nM
c-Met(D1228H)ki: 2.2nM
c-Met(M1250T)ki: 4.1nM
c-Met(Y1230H)ki: 4.5nM
VEGFR2ki: 4.1μM
In vitro (25°C) DMSO 18 mg/mL (33.35 mM)
Water Insoluble
Ethanol Insoluble
In vivo 15% Captisol+citrate vehicle 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.53 mL 92.66 mL 185.32 mL
0.5 mM 3.71 mL 18.53 mL 37.06 mL
1 mM 1.85 mL 9.27 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL

*The above data is based on the productmolecular weight 539.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11055
Actions Inhibitor
CAS No. 913376-83-7
Formula C30H29N5O5
M. Wt 539.6
Purity >98%
Synonyms AMG458, AMG 458

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy AMG-458 | AMG-458 Supplier | purchase | cost | manufacturer | order | distributor | buy 913376-83-7 | 913376-83-7 Supplier | purchase 913376-83-7 | 913376-83-7 cost | 913376-83-7 manufacturer | order 913376-83-7 | 913376-83-7 distributor