AMG-458

Catalog No.: A11055

c-Met inhibitor

AMG-458

AMG-458 Chemical Structure

CAS NO. 913376-83-7

AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2.

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$210.00
50 mg
$620.00
100 mg
$1,000.00
10mM * 1mL in DMSO
$221.00
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Biological Activity

AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2.
Targets
Target Value
c-Met(H1094R)ki: 0.5nM
c-Met(V1092I)ki: 1.1nM
c-Met(Human)ki: 1.2nM
c-Met(Mouse)ki: 2.0nM
c-Met(D1228H)ki: 2.2nM
c-Met(M1250T)ki: 4.1nM
c-Met(Y1230H)ki: 4.5nM
VEGFR2ki: 4.1μM
In vitro (25°C) DMSO 21 mg/mL (38.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol/citrate vehicle 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.53 mL 92.66 mL 185.32 mL
0.5 mM 3.71 mL 18.53 mL 37.06 mL
1 mM 1.85 mL 9.27 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL

*The above data is based on the productmolecular weight 539.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11055
Actions Inhibitor
M. Wt 539.6
Formula C30H29N5O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 913376-83-7
Synonyms AMG458, AMG 458
SMILES CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC

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