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Apoptosis inducers are compounds that trigger programmed cell death through mitochondrial, caspase or stress pathways. Apoptosis is a regulated form of cell death marked by caspase activation, chromatin condensation and cell shrinkage. Inducers serve to study how cells commit to death and as positive controls in cell death assays. Tasisulam, an acylsulfonamide, is described as acting through the intrinsic mitochondrial pathway with caspase activation. Homoharringtonine, a Cephalotaxus alkaloid, inhibits protein synthesis and lowers signal transducer and activator of transcription 3 (STAT3) signaling. Episilvestrol, a rocaglate from Aglaia plants, targets eukaryotic initiation factor 4A (eIF4A). Compounds acting on one defined apoptosis regulator are listed in sibling categories such as Bcl-2 Family and Caspase.
142I5 is a potent apoptosis antagonist targeting ML-IAP with a Lys-covalent inhibitory mechanism. It exhibits a significant inhibitory activity with an IC50 value of 11 nM, making it an effective tool for studying apoptotic pathways. This compound is ideal for research applications focused on cancer biology and therapeutic interventions related to apoptosis modulation.
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