IAP

Cat. No.

A15800

CAS No.

957135-43-2

SM-164

SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.

Cat. No.

A16996

CAS No.

1799328-86-1

Tolinapant (ASTX-660)

Synonyms: ASTX660

ASTX660 is an orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptoticctivities. 1799328-86-1 (free base) 1799328-50-9 (HCl) 1799328-90-7 (mesylate) 1799328-88-3 (sulfate)

Cat. No.

A18963

CAS No.

1001600-54-9

MV1

MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand.

Cat. No.

A20943

CAS No.

1446182-94-0

CUDC-427

Synonyms: GDC-0917

CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.

Cat. No.

A21735

CAS No.

1258392-53-8

AZD5582

AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively.

Cat. No.

A30797

CAS No.

1883545-51-4

AZD5582 dihydrochloride

AZD5582 dihydrochloride is a selective antagonist of inhibitor of apoptosis proteins (IAPs), effectively targeting the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively. This compound induces apoptosis in various tumor cell types, making it a valuable tool for cancer research. AZD5582 is utilized in studies focused on therapeutic strategies that exploit the apoptotic pathway to enhance treatment efficacy.