p53

Cat. No.

A13522

CAS No.

259199-65-0

CP 31398

CP 31398 has been shown to act as a stabilizing agent for p53, and to promotes activity of p53 in cancer cell lines.

Cat. No.

A15346

CAS No.

1217195-61-3

CP 31398 dihydrochloride

CP 31398 dihydrochloride, p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.

Cat. No.

A15348

CAS No.

72835-26-8

MIRA-1

MIRA-1 restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA.

Cat. No.

A15350

CAS No.

880813-36-5

PhiKan 083

PhiKan 083, p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions.

Cat. No.

A30156

CAS No.

2713618-08-5

Seldegamadlin

Synonyms: KT-253

Seldegamadlin is a selective p53 stabilizer and an MDM2 PROTAC degrader with a DC50 of 0.4 nM. It effectively inhibits the proliferation of RS4;11 cancer cells, demonstrating an IC50 of 0.3 nM, and induces cell cycle arrest at the G2/M phase while promoting apoptosis. By upregulating p53 activity, Seldegamadlin overcomes the p53-MDM2 feedback loop, making it a valuable tool for research in hematologic and solid tumors, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Cat. No.

A32604

CAS No.

2531685-87-5

p53 Stabilizer 2

p53 Stabilizer 2 (Compound 17a16) is a potent p53 stabilizer that enhances the stability and function of the p53 protein. This compound induces S-phase arrest and apoptosis in both p53-proficient and p53-deficient cancer cells, demonstrating its broad therapeutic potential. Mechanistically, p53 Stabilizer 2 triggers mitochondrial stress and activates critical checkpoint pathways, including NA-PKcs-dependent p53 stabilization and ATR-Chk1 axis activation. Additionally, it has shown efficacy in inhibiting tumor growth in p53-deficient xenograft models, making it a valuable tool for cancer research.

Cat. No.

A53794

CAS No.

2636846-41-6

Rezatapopt

Synonyms: PC14586

Rezatapopt (PC14586) is a small-molecule ligand that specifically targets the mutated TP53 protein, particularly the Y220C variant. By binding to a unique pocket formed by this mutation, Rezatapopt restores the structural integrity and tumor suppressor functions of p53. This compound has shown promising antitumor activity, leading to tumor inhibition and regression in mouse models with established human tumor xenografts featuring the TP53 Y220C mutation, making it a valuable tool for cancer research targeting p53 dysfunction.

Cat. No.

A53805

CAS No.

2230044-57-0

MB710

MB710 is an aminobenzothiazole derivative that functions as a stabilizer for the oncogenic p53 mutation Y220C. By tightly binding to the Y220C pocket with a Kd of 4.1 μM, MB710 effectively stabilizes the p53-Y220C variant. This compound demonstrates significant anticancer activity in cell lines expressing the p53-Y220C mutation, making it a valuable tool for research in cancer biology and therapeutic development.

Cat. No.

A53812

CAS No.

2746371-35-5

Mutant p53 modulator-1

Mutant p53 modulator-1 is a targeted modulator of mutant p53 protein. It exhibits potential to inhibit the progression of cancers harboring p53 mutations, making it a valuable tool for cancer research. This compound may aid in the development of therapeutic strategies aimed at restoring p53 function in tumor cells, thereby providing insights into the treatment of p53-related malignancies.

Cat. No.

A53815

CAS No.

2413987-20-7

PK9327

PK9327 is a small-molecule modulator that targets the MDM2-p53 interaction, specifically stabilizing mutant p53 proteins that harbor cavity-creating mutations. By enhancing the stability of these mutant forms, PK9327 has the potential to restore p53 functionality and promote apoptotic signaling in cancer cells. This reagent is valuable for research applications focused on cancer therapeutics and the exploration of p53 pathway dynamics in malignancies.

Cat. No.

A53820

CAS No.

380314-37-4

PK095

PK095 is a p53 mutant stabilizer that enhances the stability and function of mutated forms of the p53 protein. This compound is primarily utilized in cancer research, where it aids in the investigation of p53-related pathways and mechanisms of tumorigenesis. Its ability to stabilize p53 mutants makes it a valuable tool for studying therapeutic strategies targeting p53 abnormalities in various cancer models.

Cat. No.

A53850

CAS No.

3114732-99-6

p53-Y220C/PLK1 modulator-1

p53-Y220C/PLK1 modulator-1 is a novel dual modulator targeting the p53-Y220C mutation and Polo-like kinase 1 (PLK1). This compound exhibits significant biological activity in cancer research, providing a potential therapeutic avenue for tumors harboring the p53-Y220C alteration. Its application in cellular and molecular studies can facilitate the exploration of p53-mediated pathways and PLK1 functionality in oncogenesis.

Cat. No.

A53852

CAS No.

38470-63-2

Antitumor agent-202

Antitumor agent-202 is a stabilizer of the p53 Y220C mutant, specifically targeting the mutated protein to enhance its functional activity. This compound demonstrates a selective inhibitory effect on the proliferation of tumor cells harboring the p53 Y220C mutation. It serves as a valuable tool in the exploration of therapeutic strategies for cancers associated with this specific mutation, facilitating research into potential treatments and cellular mechanisms.

Cat. No.

A53889

CAS No.

7470-44-2

Safrole oxide

Safrole oxide is a p53 modulator that enhances the expression of the p53 tumor suppressor protein, facilitating cell cycle arrest and promoting apoptosis. This compound effectively induces apoptosis in lung cancer cells while avoiding necrotic cell death. Safrole oxide is valuable for research focused on lung cancer mechanisms and therapeutic strategies.

Cat. No.

A53892

CAS No.

3107623-69-5

P53 mutant stabilizer-1

P53 mutant stabilizer-1 is a covalent stabilizer specifically designed to target and stabilize mutant forms of the p53 protein. By restoring the wild-type function of p53 mutants, it serves as a valuable tool in cancer research, particularly in studies focused on cancers associated with p53 mutations. This compound enhances the understanding of p53-related pathways and potential therapeutic strategies for p53-mutated tumors.

Cat. No.

A53893

CAS No.

2636847-01-1

Mutant p53 modulator-2

Mutant p53 Modulator-2 (Compound 1988) selectively targets and restores the function of mutant p53 proteins, facilitating the reactivation of tumor suppressor activity. This compound has demonstrated significant biological activity in promoting cell cycle arrest and apoptosis in cancer cells harboring p53 mutations. It is valuable for research applications focused on cancer therapeutics and understanding the role of p53 in tumorigenesis.

Cat. No.

A53897

CAS No.

1446352-68-6

PK7242

PK7242 is a potent inducer of mutant p53 reactivation, specifically targeting the p53-Y220C variant in cancer cells. This compound promotes growth inhibition, triggers cell-cycle arrest, and initiates apoptosis in tumor cells harboring the Y220C mutation. PK7242 is a valuable tool for investigating therapeutic strategies aimed at targeting p53 deficiencies in cancer research.