TNF-α

Cat. No.

A10522

CAS No.

191732-72-6

Lenalidomide (CC-5013)

Synonyms: Revlimid; CC-5013

Lenalidomide is a derivative of thalidomide. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the micro environment support for tumor cells, and immunomodulatory role. It induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.

Cat. No.

A25239

CAS No.

158983-23-4

VDX-111

VDX-111 is a necroptosis inducer that functions as an analog of vitamin D. It exerts cytotoxic effects in ovarian cancer cells by upregulating the RIPK1/RIPK3 pathway, leading to necroptotic cell death. Additionally, VDX-111 promotes cytokine expression and demonstrates significant antitumor activity in murine models, making it a valuable tool for cancer research focused on necroptosis.

Cat. No.

A25553

CAS No.

66754-13-0

D-Trimannuronic acid

D-Trimannuronic acid, a TNF receptor activator derived from alginate oligomers in seaweed, stimulates the secretion of TNF-α in mouse macrophage cell lines. This compound is valuable in research focused on inflammatory responses, pain mechanisms, and vascular dementia. Its unique biological activity provides insights into immune modulation and related therapeutic areas.

Cat. No.

A26200

CAS No.

2070014-90-1

LY 303511 hydrochloride

LY 303511 hydrochloride is a structural analogue of LY294002 and acts as a TNF receptor activator. It enhances the sensitivity of SHEP-1 neuroblastoma cells to TRAIL, making it a valuable tool for investigating apoptosis mechanisms in cancer research. Additionally, LY 303511 reversibly blocks potassium currents in MIN6 insulinoma cells with an IC50 value of 64.6 ± 9.1 μM, facilitating studies in insulin secretion and pancreatic function.