Catalog No.
Product Name
Application
Product Information
Citations
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NAMPT inhibitor
STF 118804 is a highly specific NAMPT inhibitor that reduces the viability of most B-ALL cell lines with high potency IC50 values in the low nanomolar range and improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia. -
TrxR1/CRM1 inhibitor
Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). -
XOR Inhibitor
Topiroxostat (FYX-051) is a novel and potent xanthine oxidoreductase (XOR) inhibitor with IC50 value of 5.3 nM. -
PAI-1 inhbitor
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM.- Saijo A, .et al. , Cancer Lett, 2018, May 1;421:17-27 PMID: 29448000
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metalloendopeptidase inhibitor
Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor. -
Lp-PLA2 Inhibitor
Darapladib is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor . -
Factor Xa inhibitor
Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM- Daniël Verhoef, .et al. , Nat Commun, 2017, 8: 528 PMID: 28904343
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Tph1 inhibitor
LP-533401 is a small molecule inhibitor of Tph1.- Dongna Li, .et al. , Sci Rep, 2024, Aug 2;14(1):17951 PMID: 39095450
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Phospholipase C inhibitor
U 73122 is a phospholipase C inhibitor. It inhibits agonist-induced platelet aggregation with IC50 values of 1-5 uM.- Ke Qian, .et al. , EBioMedicine, 2023, Dec:98:104863 PMID: 37950995
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glucosidase I/II inhibitor
Deoxynojirimycin is a Maltase-glucoamylase (a-glucosidase I and II) inhibitor. It interferes with N-linked glycosylation. - Afegostat D-tartrate was an experimental drug for the treatment of certain forms of Gaucher's disease. The substance was used in form of the tartrate. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone.
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IDH1 inhibitor
AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. -
IDO inhibitor
Indoximod is a methylated tryptophan with anti-immunosuppressive activity. - ASP9521 is a novel, selective, orally bioavailable inhibitor of 17??-hydroxysteroid dehydrogenase type 5 (17bHSD5, AKR1C3).
- Belen Crespo, .et al. , Int J Mol Sci, 2024, Jan 25;25(3):1471 PMID: 38338747
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FTase Inhibitor
FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. - Phytic Acid is a constituent of wheat bran shown to have antineoplastic action in colon carcinogenesis.
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5-lipoxygenase inhibitor
Esculetin, a phenolic compound, acts as a 5-LO (5-lipoxygenase, 5-LOX) inhibitor. - Monoammoniumglycyrrhizinate is a constituent of the licorice root that has vital anti-viral activities that have been shown to inhibit the expression of 11_?HSD2 (11_?hydroxysteroid dehydrogenase type 2) via an indirect mechanism.
- Jung-Ho Lee, .et al. , J Nat Prod, 2021, Sep 24;84(9):2612-2616 PMID: 34411479
- 3-butylidenephthalide from Ligusticum porteri , an α-glucosidase inhibitor.
- Dihydroberberine is an inhibitor of pancreatic lipase with IC50 value of 8 mg/ml.
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AhR agonist
Norisoboldine, an alkaloid compound isolated from Radix Linderae, inhibits synovial angiogenesis in adjuvant-induced arthritis rats by moderating Notch1 pathway-related endothelial tip cell phenotype. - Ethyl Ferulate induces heme oxygenase-1 and protects rat neurons against oxidative stress.
- Licochalcone C was synthesized from commercially available 2,4-dihydroxybenzaldehde by using regioselective Al2O3-mediated C-prenylation followed by conventional Claisen-Schmidt condensation in basic condition.
- Atractyloside is a natural heteroglucoside produced in some plants, including A. gummifera.
- 24R,25-Dihydroxyvitamin D3 is a vitamin D metabolite, a dihydroxylated form of the seco-steroid.
- 1alpha-Hydroxy VD4 , a 1alpha(OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells.
