Catalog No.
Product Name
Application
Product Information
Citations
- Calcium D-Panthotenate is a water-soluble vitamin and an essential nutrient for many animals.
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lipase inhibitor
Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. -
FAAH inhibitor
JNJ-42165279 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. - Lometrexol is a folate analog antimetabolite with antineoplastic activity.
- Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.
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TPPII inhibitor
Butabindide oxalate is a selective and potent inhibitor of TPPII (tripeptidyl peptidase II). -
HSP90 inhibitor
Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 activity with IC50 value of μM by binding to the ATP-binding site. -
HSP70 inducer
TRC 051384, belonging to substituted 2-propen-1-one class, is a potent inducer of heat shock protein 70 (HSP70) [1]. Induction of HSP70 is a natural response of stressed cells that protects neuronal cells from a variety of insults including acute ischemia. -
SREBP inhibitor
Fatostatin Hydrobromide is an inhibitor of sterol regulatory element-binding protein (SREBP). -
PDE5 inhibitor
Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. -
alcohol dehydrogenase inhibitor
Fomepizole is an alcohol dehydrogenase inhibitor used for the treatment of ethylene glycol and methanol poisonings in adults. - Eflornithine hydrochloride, hydrate is a drug found to be effective in the treatment of facial hirsutism.
- Pyridoxamine is one form of vitamin B6. Chemically it is based on a pyridine ring structure, with hydroxyl, methyl, aminomethyl, and hydroxymethyl substituents.
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CYP2C9 inhibitor
Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM. -
pan-RARs agonist
AGN 194310 is a potent and selective pan-RARs agonist with Kd values of 3/2/5 nM for RARα/β/γ respectively. -
RARα agonist
AGN 195183 is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ. -
RARα antagonist
AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). -
RAR agonist
AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR. -
RARγ antagonist
AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ. -
PPAR agonist
Bezafibrate is the first clinically tested dual and pan-PPAR co-agonist. -
PPARβ/δ inverse agonist
DG-172 is an orally active potent PPARβ/δ inverse agonist (IC50 = 26.9 nM). DG-172 inhibits Angptl4 gene expression in mouse myoblasts (IC50 = 9.5 nM) in vitro. - Etretinate is a second-generation retinoid to treat severe psoriasis; has been replaced by acitretin, a safer metabolite of etretinate.
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Thiamin antagonist
Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake. -
Tryptophan hydroxylase inhibitor
4-Chloro-DL-phenylalanine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). - Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.
- Choline bitartrate is a form of the nutrient choline which is found in foods.
- Choline chloride is a quaternary ammonium salt used as an additive for animal feed.
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glucose metabolism inhibitor
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase. -
iron-chelating drug
Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload.
