- Cat. No.
- A20781
Hemin
Synonyms: Hemin chloride
Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.
In stock
View Details
-
-
- Cat. No.
- A22449
Coniferaldehyde
Synonyms: Ferulaldehyde
Coniferaldehyde (Ferulaldehyde), isolated from the ethanol extract of Vitex rotundifolia fruits, is an effective inducer of heme oxygenase-1 (HO-1).
In stock View Details -
- Cat. No.
- A24984
Co(III) protoporphyrin IX chloride
Synonyms: Protoporphyrin IX cobaltic chloride; CoPPIX-Cl
Co(III) protoporphyrin IX chloride is a known inducer of heme oxygenase-1 (HO-1). This compound exhibits anti-inflammatory and antibacterial activities, making it valuable in the study of various pathological conditions. It is particularly useful in research involving ischemia-reperfusion injury models, providing insights into potential therapeutic strategies.
In stock View Details -
- Cat. No.
- A26406
HPO-DAEE
Synonyms: 4-Hydroperoxy-2-decenoic acid ethyl ester
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) acts as an inducer of heme oxygenase-1 (HO-1) through the activation of the Nrf2-antioxidant response element (ARE) signaling pathway. This compound promotes the upregulation of various antioxidant genes, providing protective effects against oxidative stress. Additionally, HPO-DAEE exhibits histone deacetylase inhibition, leading to increased expression of extracellular superoxide dismutase via histone acetylation. It has demonstrated efficacy in mitigating cell death induced by 6-hydroxydopamine through the activation of both the Nrf2-ARE and eIF2α-ATF4 pathways, making it a valuable tool for research in oxidative stress-related studies.
In stock View Details -
- Cat. No.
- A26993
Ferroptosis inducer-2
Ferroptosis inducer-2 is a potent inducer of heme oxygenase-1 (HO-1) that facilitates the process of ferroptosis. It demonstrates significant anticancer activity against triple-negative breast cancer (TNBC) cells by promoting iron-dependent cell death. This compound is valuable for research focused on exploring the mechanisms of ferroptosis and developing novel therapeutic strategies for cancer treatment.
In stock View Details -
- Cat. No.
- A38870
CP-312
CP-312 is a potent inducer of Heme Oxygenase-1 (HO-1), which plays a critical role in the cellular response to oxidative stress. By enhancing the expression of HMOX1, CP-312 supports the viability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). This compound is primarily utilized in research applications focusing on cardiovascular protection and oxidative stress mitigation in cardiac cells.
In stock View Details -
- Cat. No.
- A38940
Cobalt protoporphyrin IX
Synonyms: Co-PPIX
Cobalt protoporphyrin IX (Co-PPIX) is a specific inducer of heme oxygenase-1 (HO-1). This compound demonstrates significant antiviral activity against Influenza A virus (IAV) and is widely used in research to investigate the protective roles of HO-1 in various disease models. Co-PPIX serves as a valuable tool for studying the signaling pathways involved in oxidative stress and inflammation.
Out of stock
All 3 sizes -
- Cat. No.
- A39208
HIF-PHD-IN-3
HIF-PHD-IN-3 is a potent inducer of heme oxygenase-1 (HO-1) through inhibition of hypoxia-inducible factor prolyl hydroxylases (HIF-PHDs). This compound exhibits cardioprotective properties, making it valuable in research focused on cardiac cell survival and stress responses. HIF-PHD-IN-3 is primarily utilized in studies investigating the role of HO-1 in cardiovascular health and various pathophysiological conditions.
In stock View Details -
- Cat. No.
- A75263
Hemoglobin
Hemoglobin is an iron-containing protein found in red blood cells that primarily functions in oxygen transport and binding. It plays a crucial role in gas exchange by transporting carbon dioxide, nitric oxide, hydrogen sulfide, and sulfide. Additionally, hemoglobin acts as an inducer of heme oxygenase-1 (HO-1), contributing to antioxidant defense in tissues by absorbing excess oxygen. Its biological activity makes it a valuable reagent for studies in oxygen metabolism, respiratory physiology, and redox signaling.
In stock View Details -
- Cat. No.
- A75268
Mn(III) Protoporphyrin IX chloride
Synonyms: Manganese(III) Protoporphyrin IX Chloride
Mn(III) Protoporphyrin IX Chloride is a potent inducer of heme oxygenase (HO) that enhances the expression of δ-aminolevulinate synthase and HO genes in chick embryo liver cells at a concentration of 10 μM. This metalloporphyrin is relevant for studying heme biosynthesis and degradation pathways. Additionally, Mn(III) protoporphyrin IX chloride has been utilized in the development of nanobialys for magnetic resonance imaging (MRI) of fibrin clots in vitro, as well as in the synthesis of metalloporphyrin conjugates with microperoxidase activity, further expanding its applications in chemical research.
In stock View Details -
- Cat. No.
- A75269
Probucol dithiobisphenol
Synonyms: DTBP
Probucol dithiobisphenol (DTBP) is a potent inducer of heme oxygenase 1 (HO-1) with notable antioxidant properties. It effectively inhibits atherosclerotic lesions in the aorta of Apoe−/− mice and promotes re-endothelialization, thereby reducing restenosis in rabbit arterial injury models. This compound is orally active, making it a valuable reagent for investigating vascular health and potential therapeutic applications in cardiovascular diseases.
Out of stock
All 3 sizes