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Mitochondrial Metabolism

Mitochondrial metabolism compounds act on the respiratory chain, energy coupling and redox balance of mitochondria. In 1961 Mitchell proposed that phosphorylation is coupled to electron transfer through a chemiosmotic mechanism. In this model a proton gradient across the inner membrane drives adenosine triphosphate (ATP) synthase in oxidative phosphorylation (OXPHOS). Rotenone inhibits complex I of the electron transport chain, and oligomycin A blocks ATP synthase. Gboxin, reported in 2019, is an OXPHOS inhibitor that suppresses the growth of glioblastoma cells. Mito-TEMPO is a mitochondria-targeted antioxidant that scavenges superoxide in the matrix. Meldonium inhibits carnitine biosynthesis and so limits fatty acid transport into mitochondria. The set is mixed and also lists compounds with secondary mitochondrial links, such as the fluoroquinolone ciprofloxacin.

2 Items

  • Z16078526
    Cat. No.
    A40767
    CAS No.
    852222-94-7

    Z16078526

    Z16078526 is a potent Ucp1 inducer that enhances endogenous Ucp1 expression and promotes p38 MAPK phosphorylation and lipolysis in primary mouse brown adipocytes. It effectively activates thermogenic gene expression and increases mitochondrial activity through uncoupled respiration. Additionally, Z16078526 augments thermogenesis in mice, making it a valuable reagent for research focused on metabolism and thermogenic regulation.

    In stock View Details
    1 mg
    $25.00
    5 mg
    $60.00
    All 7 sizes
  • AST 7062601
    Cat. No.
    A65890
    CAS No.
    675197-89-4

    AST 7062601

    Synonyms: AST070

    AST 7062601 is a potent Ucp1 inducer that significantly enhances the expression of endogenous uncoupling protein 1 (Ucp1) in primary mouse brown adipocytes. UCP1 plays a crucial role in thermogenesis by facilitating the oxidation of fatty acids and dissipating energy as heat through mitochondrial uncoupling. This reagent is valuable for investigating mechanisms underlying thermogenic processes and uncoupled respiration in metabolic research.

    In stock View Details
    1 mg
    $95.00
    5 mg
    $240.00
    All 7 sizes

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