Cholesterol & Lipoprotein Metabolism

Cat. No.

A65938

CAS No.

2451589-46-9

ABCA1 inducer 2

ABCA1 Inducer 2 is a selective inducer of the ATP-binding cassette transporter A1 (ABCA1), acting primarily through the liver X receptor (LXR) pathway. This compound effectively upregulates ABCA1 expression, leading to a reduction in oxidized low-density lipoprotein (ox-LDL)-induced lipid accumulation, which in turn inhibits the formation of foam cells. Due to its ability to modulate lipid homeostasis, ABCA1 Inducer 2 is of significant interest for research on atherosclerosis and related cardiovascular diseases.

Cat. No.

A65943

CAS No.

2681270-30-2

ABCA1 inducer 3

ABCA1 Inducer 3 is a potent inducer of the ATP-binding cassette transporter A1 (ABCA1), known for its role in lipid modulation. This compound enhances ABCA1 expression and significantly upregulates hepatic Abcg5 and Abcg8 mRNA levels, promoting cholesterol efflux. Its primary research applications include investigations into lipid metabolism and the management of hyperlipidemia.

Cat. No.

A69547

CAS No.

2839627-76-6

ABCA1 inducer 1

ABCA1 Inducer 1 is a potent inducer of the ATP-binding cassette transporter A1 (ABCA1). It effectively increases ABCA1 expression and enhances the lipidation of apolipoprotein E (APOE), contributing to the reversal of multiple Alzheimer's disease phenotypes. Notably, this compound operates without elevating triglyceride levels in E3/4FAD mice expressing human APOE 3/4, making it a valuable tool for research into Alzheimer’s disease and lipid metabolism.

Cat. No.

A75849

CAS No.

75689-93-9

Imanixil

Synonyms: HOE-402(free base)

Imanixil is an orally active inducer of the low-density lipoprotein receptor (LDLR). It effectively reduces cholesterol levels by inhibiting very low-density lipoprotein (VLDL) lipid production, demonstrating potential in delaying the progression of atherosclerosis. This compound is valuable for research in the field of cardiovascular diseases, particularly atherosclerosis.