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Biological Activity
CEP-18770 is a novel orally active proteasome inhibitor with a favorable tumor selectivity profile for the treatment of MM and other malignancies responsive to proteasome inhibition.
Targets
| Chymotrypsin-like proteasome | ||||
| 3.8 nM |
| In vitro | DMSO | 73 mg/mL (176.63 mM) | |
| Water | Insoluble | ||
| Ethanol | 73 mg/mL (176.63 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.2 mL | 120.98 mL | 241.95 mL |
| 0.5 mM | 4.84 mL | 24.2 mL | 48.39 mL |
| 1 mM | 2.42 mL | 12.1 mL | 24.2 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
*The above data is based on the productmolecular weight 413.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11145 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 847499-27-8 |
| Formula | C21H28BN3O5 |
| M. Wt | 413.3 |
| Purity | >98% |
| Synonyms | CEP18770 |
| SMILES | B([[email protected]](CC(C)C)NC(=O)[[email protected]]([[email protected]@H](C)O)NC(=O)C1=CC=CC(=N1)C2=CC=CC=C2)(O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
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