OTS186935 trihydrochloride is a potent inhibitor of the protein methyltransferase SUV39H2, with an IC50 of 6.49 nM. This compound demonstrates significant anti-tumor efficacy in mouse xenograft models while exhibiting no detectable toxicity. OTS186935 trihydrochloride is also capable of modulating the production of γ-H2AX, making it a valuable tool for studying DNA damage response mechanisms in cancer research.
OTS186935 trihydrochloride is a potent inhibitor of the protein methyltransferase SUV39H2, with an IC50 of 6.49 nM. This compound demonstrates significant anti-tumor efficacy in mouse xenograft models while exhibiting no detectable toxicity. OTS186935 trihydrochloride is also capable of modulating the production of γ-H2AX, making it a valuable tool for studying DNA damage response mechanisms in cancer research.
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