CRT0105950

Catalog No.: A54778
LIMK Inhibitor
CRT0105950 is a potent LIMK inhibitor, selectively targeting LIMK1 and LIMK2 with IC50 values of 0.3 nM and 1 nM, respectively. Its primary mechanism involves the inhibition of LIM kinases, which play a crucial role in regulating actin cytoskeleton dynamics and cell motility. This reagent is valuable for investigating tumor biology and potential therapeutic pathways in cancer research.
Grouped product items
Size Price Stock Qty
1mg
$45.00
In stock
5mg
$115.00
In stock
10mg
$190.00
In stock
25mg
$390.00
In stock
50mg
$610.00
In stock
100mg
$950.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCRT0105950 is a potent LIMK inhibitor, selectively targeting LIMK1 and LIMK2 with IC50 values of 0.3 nM and 1 nM, respectively. Its primary mechanism involves the inhibition of LIM kinases, which play a crucial role in regulating actin cytoskeleton dynamics and cell motility. This reagent is valuable for investigating tumor biology and potential therapeutic pathways in cancer research.
Product Information
Catalog NumA54778
FormulaC21H16ClN3OS
Molecular Weight393.89
CAS Number1661845-86-8
SMILESOC1=CC=C(C=C1)NC2=NC=C(S2)C3=C(C=NC=C3)C4=CC=C(C=C4Cl)C
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