- Cat. No.
- A11206
Omecamtiv mecarbil (CK-1827452)
Synonyms: CK1827452
CK-1827452 is a selective cardiac specific myosin activator.
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Myosin inhibitors and activators act on the actin-based motor proteins of muscle and non-muscle cells. Myosins hydrolyze adenosine triphosphate (ATP) and convert that chemical energy into movement along actin filaments. Blebbistatin was introduced in 2003 as a selective inhibitor of non-muscle myosin II and is used to study cytokinesis and cortical tension. The catalogue lists it as (-)-Blebbistcitin together with para-Nitroblebbistatin, a photostable analog suited to imaging experiments. Omecamtiv mecarbil works in the opposite direction and accelerates the cardiac myosin ATPase cycle. ML 7 hydrochloride and ML-9 hydrochloride act upstream on myosin light chain kinase, as does the neighboring MLCK category.
Synonyms: CK1827452
CK-1827452 is a selective cardiac specific myosin activator.
Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway.
Synonyms: P-hydroxyacetophenone
4-Hydroxyacetophenone is a potent myosin activator that has demonstrated hepatoprotective and choleretic properties. This compound exhibits antiviral and anti-inflammatory activities, particularly against hepatitis B virus, and is known to inhibit cancer cell adhesion, invasion, and migration through actin remodeling. Its diverse biological activities make 4-Hydroxyacetophenone a valuable reagent for research in inflammatory diseases and cancer studies.
Synonyms: MYK-491
Danicamtiv is a selective allosteric activator of cardiac myosin, serving as a cardiac inotropic agent. It enhances cardiac systolic function while maintaining mechanical efficiency, making it a valuable tool for research on heart failure and myocardial contractility. This compound is instrumental in studying the modulation of cardiac contractile function and understanding its implications in cardiovascular diseases.