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CK-1827452 (Omecamtiv mecarbil)

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Myosin activator

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Catalog No. A11206

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CK-1827452 5mg A11206-5

Regular Price: $90.00

Special Price: $81.00

CK-1827452 10mg A11206-10

Regular Price: $160.00

Special Price: $144.00

CK-1827452 50mg A11206-50

Regular Price: $480.00

Special Price: $432.00

CK-1827452 100mg A11206-100

Regular Price: $880.00

Special Price: $792.00

CK-1827452 10mM * 1mL in DMSO A11206-10mM-D

Regular Price: $131.00

Special Price: $117.90

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CK-1827452 is a selective cardiac specific myosin activator.

CK-1827452 (Omecamtiv mecarbil)

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Publications citing Adooq Products
CK-1827452 (Omecamtiv mecarbil) Citations (7)
  • Alexandre J. S. Ribeiro,et al. Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes, Circ Res, 2017, May 12; 120(10): 1572-1583 28400398
  • Anja M. Swenson,et al. Omecamtiv Mecarbil Enhances the Duty Ratio of Human 汕-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle, J Biol Chem, 2017, Mar 3; 292(9): 3768-3778 28082673
  • N芍n芍si P Jr,et al. Omecamtiv mecarbil activates ryanodine receptors from canine cardiac but not skeletal muscle, Eur J Pharmacol, 2017, Aug 15;809:73-79 28506910
  • Horv芍th B,et al. Frequency-dependent effects of omecamtiv mecarbil on cell shortening of isolated canine ventricular cardiomyocytes, Naunyn Schmiedebergs Arch Pharmacol, 2017, Dec;390(12):1239-1246 28940010
  • Szentandrassy N,et al. Dose-dependent electrophysiological effects of the myosin activator omecamtiv mecarbil in canine ventricular cardiomyocytes, J Physiol Pharmacol, 2016, Aug;67(4):483-489 27779469
  • L Nagy,et al. The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat, Br J Pharmacol, 2015, Sep; 172(18): 4506-4518 26140433
  • Larissa Butler,et al. Enhanced characterization of contractility in cardiomyocytes during early drug safety assessment., Toxicol Sci, 2015, Jun;145(2):396-406 25820236

Chemical Information

Catalog Num A11206
Actions Activator
M. Wt 401.43
Formula C20H24FN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 873697-71-3
Synonyms CK1827452, Omecamtiv Mecarbil
SMILES code CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC
Chemical Name Methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate

Biological Activity

Description
CK-1827452 is a selective cardiac specific myosin activator.
Targets
Myosin ATPase

Solubility

Solubility (25°C) * In vitro DMSO 80 mg/mL (199.28 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.91 mL 124.55 mL 249.11mL
0.5 mM 4.98 mL 24.91 mL 49.82 mL
1 mM 2.49 mL 12.46 mL 24.91 mL
5 mM 0.5 mL 2.49 mL 4.98 mL

*The above data is based on the productmolecular weight 401.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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