CK-1827452 (Omecamtiv mecarbil)

Catalog No.: A11206

Myosin activator

CK-1827452 (Omecamtiv mecarbil)

CK-1827452 (Omecamtiv mecarbil) Chemical Structure

CAS NO. 873697-71-3

CK-1827452 is a selective cardiac specific myosin activator.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$480.00
100 mg
$880.00
10mM * 1mL in DMSO
$131.00
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  • Wanjian Tang, .et al. Dilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil, J Biol Chem, 2019, October 2 PMID: 31578282
  • Thinh T. Kieu, .et al. Omecamtiv Mecarbil Slows Myosin Kinetics in Skinned Rat Myocardium at Physiological Temperature, Biophysical Journal, 2019, 2019 PMID: 31103235
  • Alexandre J. S. Ribeiro, .et al. Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes, Circ Res, 2017, May 12; 120(10): 1572–1583 PMID: 28400398
  • Anja M. Swenson, .et al. Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle, J Biol Chem, 2017, Mar 3; 292(9): 3768–3778 PMID: 28082673
  • Nánási P Jr, .et al. Omecamtiv mecarbil activates ryanodine receptors from canine cardiac but not skeletal muscle, Eur J Pharmacol, 2017, Aug 15;809:73-79 PMID: 28506910
  • Horváth B, .et al. Frequency-dependent effects of omecamtiv mecarbil on cell shortening of isolated canine ventricular cardiomyocytes, Naunyn Schmiedebergs Arch Pharmacol, 2017, Dec;390(12):1239-1246 PMID: 28940010
  • Szentandrassy N, .et al. Dose-dependent electrophysiological effects of the myosin activator omecamtiv mecarbil in canine ventricular cardiomyocytes, J Physiol Pharmacol, 2016, Aug;67(4):483-489 PMID: 27779469
  • L Nagy, .et al. The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat, Br J Pharmacol, 2015, Sep; 172(18): 4506–4518 PMID: 26140433
  • Larissa Butler, .et al. Enhanced characterization of contractility in cardiomyocytes during early drug safety assessment., Toxicol Sci, 2015, Jun;145(2):396-406 PMID: 25820236

Biological Activity

CK-1827452 is a selective cardiac specific myosin activator.
Targets
Myosin ATPase
In vitro (25°C) DMSO 80 mg/mL (199.28 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.91 mL 124.55 mL 249.11 mL
0.5 mM 4.98 mL 24.91 mL 49.82 mL
1 mM 2.49 mL 12.46 mL 24.91 mL
5 mM 0.5 mL 2.49 mL 4.98 mL

*The above data is based on the productmolecular weight 401.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11206
Actions Activator
M. Wt 401.43
Formula C20H24FN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 873697-71-3
Synonyms CK1827452, Omecamtiv Mecarbil
SMILES CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC

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