DC-peptoid-1 is a selective binder targeting the phosphorylated Brd4 PDID domain, exhibiting a dissociation constant (Kd) of approximately 50-100 μM for human-derived substrates. This reagent specifically binds to phosphorylated PDID, showing no affinity for the non-phosphorylated variant or unrelated domains. Capable of crosslinking with its target in both solution and cell lysates, DC-peptoid-1 can efficiently capture phosphorylated PDID from complex biological samples through immobilization, while avoiding interactions with non-phosphorylated proteins or phosphoproteins from bacterial origins. Its unique selectivity positions DC-peptoid-1 as a potential alternative to phosphoprotein-specific antibodies in applications such as immunoaffinity purification.
DC-peptoid-1 is a selective binder targeting the phosphorylated Brd4 PDID domain, exhibiting a dissociation constant (Kd) of approximately 50-100 μM for human-derived substrates. This reagent specifically binds to phosphorylated PDID, showing no affinity for the non-phosphorylated variant or unrelated domains. Capable of crosslinking with its target in both solution and cell lysates, DC-peptoid-1 can efficiently capture phosphorylated PDID from complex biological samples through immobilization, while avoiding interactions with non-phosphorylated proteins or phosphoproteins from bacterial origins. Its unique selectivity positions DC-peptoid-1 as a potential alternative to phosphoprotein-specific antibodies in applications such as immunoaffinity purification.
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