We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

DNA Repair

DNA repair inhibitors and activators act on enzymes that detect and fix damaged bases and broken strands. A 1993 review estimated that hydrolysis and oxidation damage thousands of DNA bases in every cell each day. In base excision repair, 8-oxoguanine DNA glycosylase 1 (OGG1) excises oxidized guanine, and apurinic/apyrimidinic endonuclease 1 (APE1) then cuts the abasic site. TH10785 is listed as an OGG1 activator, whereas APE1-IN-1 inhibits APE1. DNA repair protein RAD52 homolog (RAD52) became a target after a 2011 study found its loss lethal in cells lacking breast cancer susceptibility protein 2 (BRCA2). D-I03 inhibits RAD52, HAMNO blocks replication protein A (RPA), and CD00509 inhibits tyrosyl-DNA phosphodiesterase 1 (TDP1).

2 Items

  • UNC-2170
    Cat. No.
    A37794
    CAS No.
    1648707-58-7

    UNC-2170

    UNC-2170 is a selective fragment-like ligand targeting 53BP1, exhibiting an IC50 of 29 µM and a Kd of 22 µM. With over 17-fold selectivity against nine other methyl-lysine reader proteins, UNC-2170 effectively binds to 53BP1, a key player in DNA Damage Repair (DDR) pathways. Its primary application lies in studying the recruitment of 53BP1 to double-strand breaks (DSB), facilitating research in genomic stability and repair mechanisms.

    In stock View Details
    5 mg
    $35.00
    10 mg
    $55.00
    All 6 sizes
  • UNC3474
    Cat. No.
    A53808
    CAS No.
    1648707-79-2

    UNC3474

    UNC3474 is a small molecule ligand that selectively binds to the aromatic methyl-lysine binding cage of 53BP1, exhibiting a dissociation constant (Kd) of 1.0 ± 0.3 μM. This binding inhibits the recruitment of 53BP1 to DNA double-strand breaks (DSBs) by stabilizing a pre-existing autoinhibited state of the protein within cells. UNC3474 is a valuable tool for researchers studying DNA damage response mechanisms and the regulation of genomic stability.

    In stock View Details
    5 mg
    $130.00
    10 mg
    $220.00
    All 4 sizes

2 Items

Added to your cart

View Cart Checkout

    Loading...